Title : Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting.

Pub. Date : 2001 Nov 2

PMID : 11526109






1 Functional Relationships(s)
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1 Mutations of phosphoinositide-binding sites in both the pleckstrin homology and phosphotyrosine-binding domains significantly reduced the ability of Myc-tagged IRS-1 to translocate to the plasma membrane following insulin stimulation. Phosphatidylinositols insulin receptor substrate 1 Homo sapiens