Title : The N-terminal region of Sgs1, which interacts with Top3, is required for complementation of MMS sensitivity and suppression of hyper-recombination in sgs1 disruptants.

Pub. Date : 2001 Jul

PMID : 11523801






1 Functional Relationships(s)
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1 Disruption of the SGS1 gene is associated with high sensitivity to methyl methanesulfonate (MMS) and hydroxyurea (HU), and with hyper-recombination phenotypes, including interchromosomal recombination between heteroalleles. Hydroxyurea ATP-dependent DNA helicase SGS1 Saccharomyces cerevisiae S288C