Pub. Date : 2001 Sep 1
PMID : 11522452
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells. | Glutathione | caspase 3 | Homo sapiens |
| 2 | Now we show that the inhibition of caspase-3 by curcumin, which is accompanied by attenuation of internucleosomal DNA fragmentation, may be due to elevation of glutathione, which increased in curcumin-treated cells to 130% of control. | Glutathione | caspase 3 | Homo sapiens |
| 3 | We have demonstrated that glutathione depletion does not itself induce apoptosis in Jurkat cells; though, it can release cytochrome c from mitochondria and caspase-3 from inhibition by curcumin, as shown by Western blot. | Glutathione | caspase 3 | Homo sapiens |