Title : Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells.

Pub. Date : 2001 Sep

PMID : 11518779






2 Functional Relationships(s)
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1 Patients with IgAN displayed increased levels of IgA glycoforms exposing sialic acid in alpha2,6 linkage with N-acetylgalactosamine (Neu5Acalpha2,6GalNAc) (P < 0.02) and GalNAc (P < 0.05), indicating truncation of O-linked glycans of IgA1. N-acetylgalactosaminuronic acid IGAN1 Homo sapiens
2 In conclusion, a significant modulation of several human MC functions exerted by serum IgA with increased exposure of GalNAc, Neu5Acalpha2,6GalNAc, and mannose residues isolated from IgAN patients is reported for the first time. N-acetylgalactosaminuronic acid IGAN1 Homo sapiens