Pub. Date : 2001 Sep
PMID : 11518759
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bile acids and FXR repressed endogenous CYP7A1 but stimulated alpha-fetoprotein transcription factor (FTF) and small heterodimer partner (SHP) mRNA expression in HepG2 cells. | Bile Acids and Salts | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 2 | Results revealed that FTF was a dominant negative factor that was induced by bile acid-activated FXR to inhibit both CYP7A1 and SHP transcription. | Bile Acids and Salts | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 3 | Differential regulation of FTF and SHP expression by bile acids may explain the wide variation in CYP7A1 expression and the rate of bile acid synthesis and regulation in different species. | Bile Acids and Salts | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 4 | Differential regulation of FTF and SHP expression by bile acids may explain the wide variation in CYP7A1 expression and the rate of bile acid synthesis and regulation in different species. | Bile Acids and Salts | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |