Title : Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.

Pub. Date : 2001 Oct 26

PMID : 11517218






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutation at Thr-668 of APP abolished the effect of Fe65 on APP maturation. Threonine amyloid beta precursor protein binding family B member 1 Homo sapiens
2 The present results suggest that the phosphorylation of O-glycosylated mature APP at Thr-668 causes a conformational change in its cytoplasmic domain that prevents binding of Fe65 in neurons and may lead to an alteration in the production of Abeta. Threonine amyloid beta precursor protein binding family B member 1 Homo sapiens