Title : B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.

Pub. Date : 2001 Aug 20

PMID : 11514608






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 BCR ligation induced rapid tyrosine-phosphorylation of HPK1 mainly by Syk and Lyn, resulting in its association with BASH and catalytic activation. Tyrosine mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
2 The functional SH2 domain of BASH and Tyr-379 within HPK1 which we identified as a Syk-phosphorylation site were both necessary for interaction of both proteins and efficient HPK1 activation after BCR stimulation. Tyrosine mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
3 The functional SH2 domain of BASH and Tyr-379 within HPK1 which we identified as a Syk-phosphorylation site were both necessary for interaction of both proteins and efficient HPK1 activation after BCR stimulation. Tyrosine mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
4 These results reveal a novel BCR signaling pathway leading to the activation of HPK1 and subsequently IKKbeta, in which BASH recruits tyrosine-phosphorylated HPK1 into the BCR signaling complex. Tyrosine mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
5 These results reveal a novel BCR signaling pathway leading to the activation of HPK1 and subsequently IKKbeta, in which BASH recruits tyrosine-phosphorylated HPK1 into the BCR signaling complex. Tyrosine mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens