Title : T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.

Pub. Date : 2001 Aug 20

PMID : 11514605






3 Functional Relationships(s)
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1 After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. Tyrosine T cell receptor alpha variable 6-3 Mus musculus
2 After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. Tyrosine T cell receptor alpha variable 6-3 Mus musculus
3 Furthermore, we showed that Y292 and Y315 are dispensable for the TCR-induced tyrosine phosphorylation of Cbl and Vav1, respectively. Tyrosine T cell receptor alpha variable 6-3 Mus musculus