Title : Impact of GSTM1 on aromatic-DNA adducts and p53 accumulation in human skin and lymphocytes.

Pub. Date : 2001 Aug

PMID : 11505223






2 Functional Relationships(s)
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1 In cultured lymphocytes treated with 2.5 microM BPDE for 18 h, increased levels of p53 were found, which were positively related to BPDE-DNA adduct levels assessed by ICC (rs = 0.66, P < 0.001) and 32P-postlabelling (rs = 0.56, P < 0.001) and appeared to be higher in GSTM1(-/-) than in GSTM1(+) subjects (P = 0.003). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens
2 In cultured lymphocytes treated with 2.5 microM BPDE for 18 h, increased levels of p53 were found, which were positively related to BPDE-DNA adduct levels assessed by ICC (rs = 0.66, P < 0.001) and 32P-postlabelling (rs = 0.56, P < 0.001) and appeared to be higher in GSTM1(-/-) than in GSTM1(+) subjects (P = 0.003). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens