Title : Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer.

Pub. Date : 2001 Jan

PMID : 11496833






1 Functional Relationships(s)
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1 Crude human enzyme was shown to have a similar substrate profile to recombinant Type 3 17beta-HSD from the same source as determined by the low Km/Vmax ratio for the reduction of androstenedione compared to the oxidation of testosterone, and a low level of activity in reduction of oestrone. Testosterone hydroxysteroid 17-beta dehydrogenase 7 Homo sapiens