Title : Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y(2) receptor antagonist, in vivo.

Pub. Date : 2001 Aug

PMID : 11487518






4 Functional Relationships(s)
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1 Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y(2) receptor antagonist, in vivo. BIIE 0246 neuropeptide Y receptor Y2 Sus scrofa
2 BIIE0246, a recently introduced non-peptide neuropeptide Y (NPY) Y(2) receptor antagonist, was pharmacologically characterized in vivo, on vascular responses evoked in the anaesthetized pig. BIIE 0246 neuropeptide Y receptor Y2 Sus scrofa
3 It is concluded that BIIE0246 is a highly potent and selective NPY Y(2) receptor antagonist, albeit with rather short duration of action, in vivo. BIIE 0246 neuropeptide Y receptor Y2 Sus scrofa
4 BIIE0246 thus represents the first interesting tool for studies on NPY Y(2) receptor-mediated transmission in vivo. BIIE 0246 neuropeptide Y receptor Y2 Sus scrofa