Title : The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin.

Pub. Date : 2001 Aug 1

PMID : 11483510






1 Functional Relationships(s)
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1 Here we find that upon ATP binding, mimicked by the non-hydrolysable analog AMP-PNP (5"-adenylyl-imido-diphosphate), to both CCT-alpha-actin and CCT- beta-tubulin complexes, the chaperonin component undergoes concerted movements of the apical domains, resulting in the cavity being closed off by the helical protrusions of the eight apical domains. Adenosine Triphosphate t-complex 1 Homo sapiens