Title : Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

Pub. Date : 2001 Aug

PMID : 11479630






3 Functional Relationships(s)
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1 A cancer cell line selected for resistance to Et743 had chromosome alterations in a region that included the gene implicated in the hereditary disease xeroderma pigmentosum (XPG, also known as Ercc5). Trabectedin ERCC excision repair 5, endonuclease Homo sapiens
2 A cancer cell line selected for resistance to Et743 had chromosome alterations in a region that included the gene implicated in the hereditary disease xeroderma pigmentosum (XPG, also known as Ercc5). Trabectedin ERCC excision repair 5, endonuclease Homo sapiens
3 Xeroderma pigmentosum cells deficient in the NER genes XPG, XPA, XPD or XPF were resistant to Et743, and sensitivity was restored by complementation with wild-type genes. Trabectedin ERCC excision repair 5, endonuclease Homo sapiens