Title : Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene.

Pub. Date : 2001 Oct 19

PMID : 11479321






1 Functional Relationships(s)
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1 The gene for the single subunit, rotenone-insensitive, and flavone-sensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that lack the essential mitochondrial DNA (mtDNA)-encoded subunit ND4. Rotenone NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C