Title : The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment.

Pub. Date : 2001 Aug 1

PMID : 11468165






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels. SB 203580 C-C motif chemokine ligand 2 Homo sapiens
2 Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels. SB 203580 C-C motif chemokine ligand 2 Homo sapiens
3 In addition, SB203580 decreased IL-8 and MCP-1 production induced by the thrombin receptor-1 agonist peptide (TRAP), suggesting functional links between the thrombin G protein-coupled receptor and the p38 MAPK pathway. SB 203580 C-C motif chemokine ligand 2 Homo sapiens