Title : Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.

Pub. Date : 2001 Aug

PMID : 11454726






4 Functional Relationships(s)
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1 Hepatic injury of TA in DR rats pretreated with diallyl sulfide (DAS), a well known irreversible in vivo inhibitor of CYP2E1, was significantly decreased (60%) at 24 h. CCl(4) (4 ml/kg i.p. allyl sulfide cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus
2 Hepatic injury of TA in DR rats pretreated with diallyl sulfide (DAS), a well known irreversible in vivo inhibitor of CYP2E1, was significantly decreased (60%) at 24 h. CCl(4) (4 ml/kg i.p. allyl sulfide cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus
3 ), a known substrate of CYP2E1, caused lower liver injury and higher animal survival confirming inhibition of CYP2E1 by DAS pretreatment. allyl sulfide cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus
4 ), a known substrate of CYP2E1, caused lower liver injury and higher animal survival confirming inhibition of CYP2E1 by DAS pretreatment. allyl sulfide cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus