Title : 12-O-tetradecanoylphorbol-13-acetate induces Epstein-Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase.

Pub. Date : 2001 Jul 20

PMID : 11448162






3 Functional Relationships(s)
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1 12-O-tetradecanoylphorbol-13-acetate induces Epstein-Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase. Tetradecanoylphorbol Acetate JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Electrophoretic mobility shift assays demonstrated that transcription factors NF-kappaB and AP-1 were also activated by TPA in a time-dependent manner. Tetradecanoylphorbol Acetate JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 These results show that TPA induces EBV reactivation via NF-kappaB and AP-1 and that PKC is an important mediator in regulating gene expression leading to EBV reactivation after TPA treatment of GT38 cells. Tetradecanoylphorbol Acetate JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens