Title : Involvement of FAN in TNF-induced apoptosis.

Pub. Date : 2001 Jul

PMID : 11435466






1 Functional Relationships(s)
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1 We have now shown that stable expression in human fibroblasts of a dominant negative form of FAN abrogates TNF-induced ceramide generation from sphingomyelin hydrolysis and reduces caspase processing, thus markedly inhibiting TNF-triggered apoptosis. Sphingomyelins tumor necrosis factor Homo sapiens