Pub. Date : 2001 May
PMID : 11432693
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE AND METHODS: The primary objective was to determine whether neuronal NO synthase (nNOS) is involved in PCP-induced behaviours and neuronal activation, as measured by the expression of c-Fos. | Phencyclidine | nitric oxide synthase 1, neuronal | Mus musculus |
| 2 | After characterizing a PCP mouse model (dose-response study, Experiment 1), we measured PCP-induced effects in mice treated with nNOS antisense oligodeoxynucleotides (AS-ODNs) (Experiment 2), and in nNOS knockout (nNOS-/-) mice (Experiment 3). | Phencyclidine | nitric oxide synthase 1, neuronal | Mus musculus |
| 3 | In the nNOS-/- mice, PCP induced less behaviour and a decrease in Fos-LIR in the frontal cortex and midline limbic areas, when compared to wild-type littermate controls. | Phencyclidine | nitric oxide synthase 1, neuronal | Mus musculus |
| 4 | Furthermore, we show that an intact nNOS system is necessary to obtain PCP-induced effects. | Phencyclidine | nitric oxide synthase 1, neuronal | Mus musculus |