Title : Synthesis of a novel C-10 spiro-epoxide of paclitaxel.

Pub. Date : 2001 Jul 9

PMID : 11425537






2 Functional Relationships(s)
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1 New analogues of paclitaxel (1a, active constituent of Taxol) were synthesized containing an epoxide at the C-10 position. Epoxy Compounds homeobox C10 Homo sapiens
2 The introduction of the epoxide was carried out by selective removal of the C10-acetate followed by protection of the C2"- and C7-hydroxyl groups. Epoxy Compounds homeobox C10 Homo sapiens