Title : N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N_hydroxy-PhIP by specific human UDP-glucuronosyltransferases.

Pub. Date : 2001 Jul

PMID : 11408353






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Incubations containing PhIP as substrate formed direct PhIP-glucuronides in microsomes expressing UGT1A1, UGT1A4 and UGT1A9 but at levels averaging 53-fold lower than when N-hydroxy-PhIP was used as the substrate. phip-glucuronides UDP glucuronosyltransferase family 1 member A4 Homo sapiens