Pub. Date : 2001 Jul
PMID : 11404268
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel mechanisms in murine nitrofen-induced pulmonary hypoplasia: FGF-10 rescue in culture. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 2 | We evaluated the role of the key pulmonary morphogenetic gene fibroblast growth factor-10 (Fgf10) in murine nitrofen-induced primary lung hypoplasia, which is evident before the time of diaphragm closure. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 3 | We evaluated the role of the key pulmonary morphogenetic gene fibroblast growth factor-10 (Fgf10) in murine nitrofen-induced primary lung hypoplasia, which is evident before the time of diaphragm closure. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 4 | In situ hybridization and competitive RT-PCR revealed a profound disturbance in the temporospatial pattern as well as a 10-fold decrease in mRNA expression level of Fgf10 but not of the inducible inhibitor murine Sprouty2 (mSpry2) after nitrofen treatment. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 5 | Exogenous FGF-10 increased branching not only of control lungs [13% (right) and 27% (left); P < 0.01] but also of nitrofen-exposed lungs [23% (right) and 77% (left); P < 0.01]. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 6 | We conclude that nitrofen inhibits Fgf10 expression, which is essential for lung growth and branching. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 7 | Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 8 | Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 9 | Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture. | nitrofen | fibroblast growth factor 10 | Mus musculus |
| 10 | Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture. | nitrofen | fibroblast growth factor 10 | Mus musculus |