Title : Different effects of genistein on molecular markers related to apoptosis in two phenotypically dissimilar breast cancer cell lines.

Pub. Date : 2001 Apr 2-27

PMID : 11400165






2 Functional Relationships(s)
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1 In elucidating these findings, it was determined that after 2 days of incubation with genistein, MCF-7 but not MDA-MB-231 cells, had significantly higher levels of p53. Genistein tumor protein p53 Homo sapiens
2 Levels of p21 increased in both of the genistein-treated cell lines, suggesting that p21 gene expression was activated but in a p53-independent manner, whereas no significant changes in levels of the pro-apoptotic protein, Bax, were found. Genistein tumor protein p53 Homo sapiens