Title : Activation of two distinct anti-proliferative pathways, apoptosis and p38 MAP kinase-dependent cell cycle arrest, by tumor necrosis factor in human melanoma cell line A375.

Pub. Date : 2001 Apr-Jun

PMID : 11399512






3 Functional Relationships(s)
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1 TNF-induced growth inhibition in both cell lines was partially suppressed by a selective p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580), whereas a combination of SB203580 and Z-VAD-fmk, an inhibitor for a wide range of caspases, completely blocked TNF-induced growth inhibition, indicating that TNF-induced growth inhibition is mediated by both p38 MAPK and caspases. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Homo sapiens
2 However, Z-VAD-fmk alone suppressed TNF-induced growth inhibition in A375-R8, but not A375-6, cells, suggesting that there may exist a TNF-induced anti-apoptotic mechanism in A375-6 cells which is lost or mutated in A375-R8 cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Homo sapiens
3 However, Z-VAD-fmk alone suppressed TNF-induced growth inhibition in A375-R8, but not A375-6, cells, suggesting that there may exist a TNF-induced anti-apoptotic mechanism in A375-6 cells which is lost or mutated in A375-R8 cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Homo sapiens