Title : Differential interaction of Cbl with Grb2 and CrkL in CD2-mediated NK cell activation.

Pub. Date : 2000 Dec

PMID : 11399323






3 Functional Relationships(s)
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1 CD2 crosslinking results in the marked tyrosine phosphorylation of Cbl in an antibody concentration- and time-dependent manner. Tyrosine CD2 molecule Homo sapiens
2 In addition, we demonstrate that CrkL associates with a large portion of tyrosine phosphorylated Cbl after CD2 stimulation of NK3.3 cells. Tyrosine CD2 molecule Homo sapiens
3 In contrast to constitutive Cbl association with Grb2, tyrosine phosphorylated Cbl interacts with CrkL via its SH2 domain only after CD2 stimulation. Tyrosine CD2 molecule Homo sapiens