Pub. Date : 2001 Jun
PMID : 11391542
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of CD81 expression by interferon alfa (IFN-alpha) and ribavirin could thereby affect the response to antiviral therapy. | Ribavirin | CD81 molecule | Homo sapiens |
| 2 | In the present study, the effects of IFN-alpha and ribavirin on CD81 protein and CD81 mRNA were assessed in peripheral blood lymphocytes (PBL) and isolated human hepatocytes by fluorescence-activated cell sorter (FACS) analysis and real-time polymerase chain reaction (PCR), respectively. | Ribavirin | CD81 molecule | Homo sapiens |
| 3 | Incubation with IFN-alpha with and without ribavirin (2.2 microg/mL) significantly reduced cell surface-associated CD81 protein (83.9 +/- 10.3% of control; P =.003). | Ribavirin | CD81 molecule | Homo sapiens |
| 4 | In conclusion, IFN-alpha and ribavirin regulate CD81 expression in vitro and in vivo. | Ribavirin | CD81 molecule | Homo sapiens |