Pub. Date : 2001 Jun
PMID : 11389717
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus. | Tetradecanoylphorbol Acetate | dihydrofolate reductase | Cricetulus griseus |
| 2 | 4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus. | Tetradecanoylphorbol Acetate | dihydrofolate reductase | Cricetulus griseus |
| 3 | 4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus. | Tetradecanoylphorbol Acetate | dihydrofolate reductase | Cricetulus griseus |
| 4 | 4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus. | Tetradecanoylphorbol Acetate | dihydrofolate reductase | Cricetulus griseus |
| 5 | TPA incubation increased the expression and activity of DHFR. | Tetradecanoylphorbol Acetate | dihydrofolate reductase | Cricetulus griseus |
| 6 | We conclude that one mechanism by which TPA enhances MTX resistance, mainly by gene amplification, is through an increase in Sp1 expression which leads to DHFR activation. | Tetradecanoylphorbol Acetate | dihydrofolate reductase | Cricetulus griseus |