Pub. Date : 2001 May
PMID : 11380624
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Similarly, TPA-induced PLD activation was reduced in Btk deficient cells, but unaffected in Lyn deficient cells. | Tetradecanoylphorbol Acetate | Bruton tyrosine kinase | Gallus gallus |
| 2 | Finally, in cells deficient in the PLC-gamma2, one of the phosphorylated substrates regulated by Syk and Btk, TPA-induced PLD activation, as well as phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis was remarkably reduced. | Tetradecanoylphorbol Acetate | Bruton tyrosine kinase | Gallus gallus |
| 3 | CONCLUSIONS: We demonstrated that the Syk, Btk and PLC-gamma2 pathways are required for TPA-induced PLD activation in DT40 cells. | Tetradecanoylphorbol Acetate | Bruton tyrosine kinase | Gallus gallus |