Title : Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.

Pub. Date : 2001 May

PMID : 11376561






2 Functional Relationships(s)
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1 CYP2A6-expressing cells (DLD-1 / CYP2A6 cells) more efficiently catalyzed the conversion of FT to 5-fluorouracil (5-FU) (2.6-fold) and the 7-hydroxylation of coumarin (7.9-fold) than cells transfected with a null construct (DLD-1 / null cells). Tegafur cytochrome P450 family 2 subfamily A member 6 Homo sapiens
2 CYP2A6-expressing cells (DLD-1 / CYP2A6 cells) more efficiently catalyzed the conversion of FT to 5-fluorouracil (5-FU) (2.6-fold) and the 7-hydroxylation of coumarin (7.9-fold) than cells transfected with a null construct (DLD-1 / null cells). Tegafur cytochrome P450 family 2 subfamily A member 6 Homo sapiens