Pub. Date : 2001 Jun 1
PMID : 11369651
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells. | Aspartic Acid | KIT proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 2 | Activating mutations of c-kit at codon 816 (Asp(816)) have been implicated in a variety of malignancies, including acute myeloid leukemia (AML). | Aspartic Acid | KIT proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 3 | Changes in the signal transduction pathways responsible for Asp(816) mutant c-Kit-mediated biologic effects are largely undefined. | Aspartic Acid | KIT proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 4 | The results of this study show that Asp(816) mutant c-Kit induces constitutive activation of signal transducer and activator of transcription 3 (STAT3) and STAT1, and up-regulates STAT3 downstream targets, Bcl-x(L) and c-myc. | Aspartic Acid | KIT proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 5 | The phosphatidylinositol-3-kinase (PI-3K)/Akt pathway, but not the Ras-mediated mitogen-activated protein (MAP) kinase pathway, is also constitutively activated by Asp(816) mutant c-Kit. | Aspartic Acid | KIT proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 6 | The investigation of altered signal transduction pathways and the resulting functional consequences mediated by Asp(816) mutant c-Kit should provide important information for the characterization of subsets of leukemia and potential molecular pathways for therapeutic targeting. | Aspartic Acid | KIT proto-oncogene, receptor tyrosine kinase | Homo sapiens |