Title : Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes.

Pub. Date : 2001 Jun

PMID : 11353758






1 Functional Relationships(s)
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1 Orphenadrine (CYP2B6 inhibitor, 500 microM) and sulfaphenazole (CYP2C9 inhibitor, 100 microM) inhibited the N-demethylase activities for both enantiomers (5 microM) in human liver microsomes by 60 to 70%, whereas cyclosporin A (CYP3A4 inhibitor, 100 microM) failed to inhibit these activities. Orphenadrine cytochrome P450 family 2 subfamily B member 6 Homo sapiens