Title : Synthesis, characterization, and labeling with 99mTc/188Re of peptide conjugates containing a dithia-bisphosphine chelating agent.

Pub. Date : 2001 May-Jun

PMID : 11353532






4 Functional Relationships(s)
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1 The first step in this approach involves the coupling of the corresponding (PH2)2S2-COOH intermediate to the N-terminus of the peptide(s). Carbonic Acid polyhomeotic homolog 2 Homo sapiens
2 In this study, (PH2)2S2-COOH BFCA was conjugated to model peptides. Carbonic Acid polyhomeotic homolog 2 Homo sapiens
3 The glycineglycine ethyl ester (GlyGlyOEt)-(PH2)2S2-COOH BFCA conjugate was converted to the hydroxymethylene phosphine form and complexed with 99mTc to produce the 99mTcO2-P2S2-GlyGlyOEt conjugate 8 in RCPs of >/=95%. Carbonic Acid polyhomeotic homolog 2 Homo sapiens
4 The results of this investigation demonstrate that the (PH2)2S2-COOH BFCA can be conveniently used as a precursor for labeling small receptor-avid peptides with diagnostic (99mTc) and therapeutic (188Re) radionuclides via the postconjugation approach in high yields. Carbonic Acid polyhomeotic homolog 2 Homo sapiens