Title : Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

Pub. Date : 2001 Jun 29

PMID : 11335710






2 Functional Relationships(s)
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1 The Mek inhibitor, PD98059, blocked IL-3-driven proliferation, an effect enhanced by Deltap85 expression, suggesting that inhibition of Mek and Erks by Deltap85 contributes to the decrease in IL-3-induced proliferation in these cells but that additional pathways may also be involved. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one interleukin 3 Homo sapiens
2 The Mek inhibitor, PD98059, blocked IL-3-driven proliferation, an effect enhanced by Deltap85 expression, suggesting that inhibition of Mek and Erks by Deltap85 contributes to the decrease in IL-3-induced proliferation in these cells but that additional pathways may also be involved. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one interleukin 3 Homo sapiens