Title : Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta.

Pub. Date : 2001 May 1

PMID : 11331261






1 Functional Relationships(s)
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1 CONCLUSIONS: We therefore conclude that increased expression of sGC in the setting of tolerance reflects a chronic inhibition rather than an induction of the sGC-cGK-I pathway and may be mediated at least in part by increased vascular superoxide. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus