Title : Behavioral characteristics of olanzapine: an atypical neuroleptic.

Pub. Date : 2000 Apr

PMID : 11324461






1 Functional Relationships(s)
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1 CONCLUSION: Ola distinguished itself from the typical neuroleptic (e.g. haloperidol, Hal) and took resemblance of the atypical neuroleptic (e.g. clozapine, Clo) in 3 aspects: 1) the multiple receptor pharmacodynamics involving D1/D2, 5-HT2 and M-ACh receptors; 2) dose-response separation between the block of conditioned avoidance response and catalepsy induction; and 3) the specificity of action sites of firing rates upon acute drug challenge. Olanzapine histidine ammonia lyase Mus musculus