Pub. Date : 2001 Apr 27
PMID : 11322764
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We conducted the following experiments to determine whether curcumin, an antioxidant compound extracted from the spice tumeric, inhibits cell death induced by Shiga toxin (Stx) 1 and 2 in HK-2 cells, a human proximal tubule cell line. | Curcumin | hexokinase 2 | Homo sapiens |
| 2 | The protective effect of curcumin against Stx1 and Stx2-induced injury to HK-2 was not related to its antioxidant properties. | Curcumin | hexokinase 2 | Homo sapiens |
| 3 | Instead, curcumin enhanced expression of heat shock protein 70 (HSP70) in HK-2 cells under control conditions and after exposure to Stx1 or Stx2. | Curcumin | hexokinase 2 | Homo sapiens |
| 4 | Thus, curcumin inhibits Stx-induced apoptosis and necrosis in HK-2 cells in vitro. | Curcumin | hexokinase 2 | Homo sapiens |