Pub. Date : 2001 Jul 6
PMID : 11320081
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor. | Phosphatidylcholines | apolipoprotein A1 | Homo sapiens |
| 2 | However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified. | Phosphatidylcholines | apolipoprotein A1 | Homo sapiens |
| 3 | Incubation of apolipoprotein A-I with 1-palmitoyl-2-linoleoyl glycerophosphocholine proteoliposomes in the presence of 3-morpholinosydnonimine or apoAI with phosphatidylcholine hydroperoxides resulted in a significant increase in phosphatidylcholine core aldehydes with no formation of lysophosphatidylcholine. | Phosphatidylcholines | apolipoprotein A1 | Homo sapiens |
| 4 | We conclude that, upon HDL oxidation with peroxynitrite, apolipoprotein AI increases the formation of phosphatidylcholine core aldehydes that are subsequently hydrolyzed by PON1. | Phosphatidylcholines | apolipoprotein A1 | Homo sapiens |