Title : Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides.

Pub. Date : 2001 Mar 15

PMID : 11300871






1 Functional Relationships(s)
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1 Moreover, our model can be used to predict the binding affinity of PI3-K-generated phospholipids and rationalize the specificity of the Akt PH domain for PI(3,4)P2, as opposed to other phospholipids such as PI(3)P and PI(3,4,5)P3. 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'D-myo-inositol-3'-phosphate) AKT serine/threonine kinase 1 Homo sapiens