Title : Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.

Pub. Date : 2001 Apr 28

PMID : 11295216






1 Functional Relationships(s)
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1 In resistant cells apoptosis induced by free DOX depended on the activation of caspases 2, 7 and 9, while caspase 3 was not involved; this explains the low degree of apoptosis induced by free DOX in resistant cells. Doxorubicin caspase 2 Homo sapiens