Title : Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells.

Pub. Date : 2001 May

PMID : 11295047






5 Functional Relationships(s)
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1 Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells. Genistein cyclin dependent kinase inhibitor 1A Homo sapiens
2 A block of cell cycle checkpoint by dexamethasone and genistein correlates with a selective induction of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1 in a tumor suppressor p53-independent manner and abolishment of Cdk2 phosphorylation. Genistein cyclin dependent kinase inhibitor 1A Homo sapiens
3 In the present study, the effects of dexamethasone and genistein (both singly and combined) on the expression of p21 in human hepatocellular Hep G2 and colorectal Colo320 HSR carcinoma cells were evaluated. Genistein cyclin dependent kinase inhibitor 1A Homo sapiens
4 The combined effects of dexamethasone and genistein on the induction of p21 protein and activation of p21 promoter were synergistic in both cell lines. Genistein cyclin dependent kinase inhibitor 1A Homo sapiens
5 The combined effects of dexamethasone and genistein on the induction of p21 protein and activation of p21 promoter were synergistic in both cell lines. Genistein cyclin dependent kinase inhibitor 1A Homo sapiens