Title : A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

Pub. Date : 2001 Apr 10

PMID : 11287630






3 Functional Relationships(s)
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Protein Name
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1 The effect of TNF on insulin-promoted tyrosine phosphorylation of IRS-1 was blocked by inhibition of PI 3-kinase and the PTEN tumor suppressor, which dephosphorylates the lipids that mediate PI 3-kinase functions, whereas constitutively active Akt impaired insulin-promoted IRS-1 tyrosine phosphorylation. Tyrosine AKT serine/threonine kinase 1 Homo sapiens
2 Conversely, TNF inhibition of IRS-1 tyrosine phosphorylation was blocked by kinase dead Akt. Tyrosine AKT serine/threonine kinase 1 Homo sapiens
3 Inhibition of IRS-1 tyrosine phosphorylation by TNF was blocked by rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), a downstream target of Akt. Tyrosine AKT serine/threonine kinase 1 Homo sapiens