Title : GTP-dependent segregation of H-ras from lipid rafts is required for biological activity.

Pub. Date : 2001 Apr

PMID : 11283610






4 Functional Relationships(s)
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1 GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens
2 GTP-loading redistributes H-ras from rafts into bulk plasma membrane by a mechanism that requires the adjacent hypervariable region of H-ras. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens
3 GTP-loading redistributes H-ras from rafts into bulk plasma membrane by a mechanism that requires the adjacent hypervariable region of H-ras. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens
4 Our studies identify a novel protein determinant that is required for H-ras function, and show that the GTP/GDP state of H-ras determines its lateral segregation on the plasma membrane. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens