Title : Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol.

Pub. Date : 2001 Jun 1

PMID : 11278392






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The JNK inhibitor dicumarol suppressed IGF-I-mediated activation of JNK and phosphorylation of c-Jun but did not affect p38 and IkappaB phosphorylation or activation of AKT. Dicumarol insulin-like growth factor 1 Mus musculus
2 IGF-I-mediated protection from apoptosis in FL5.12/WT cells was completely suppressed by dicumarol and partially suppressed by a p38 inhibitor. Dicumarol insulin-like growth factor 1 Mus musculus