Title : 2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.

Pub. Date : 2001 Mar 15

PMID : 11266658






2 Functional Relationships(s)
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1 Kinetic analysis revealed purely competitive inhibition of 2"-O-acyl-BVaraU against TK-2-catalysed thymidine phosphorylation (K(i)/K(m): 2.3). 2"-o-acyl-bvarau thymidine kinase 2 Homo sapiens
2 However, 2"-O-acyl-BVaraU was extremely poorly converted to the corresponding arabinosyl nucleoside 5"-monophosphate by TK-2 as revealed by [gamma-(32)P]phosphate transfer studies from [gamma-(32)P]ATP. 2"-o-acyl-bvarau thymidine kinase 2 Homo sapiens