Title : Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1.

Pub. Date : 2001 Mar-Apr

PMID : 11265773






1 Functional Relationships(s)
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1 The authors designed the current study to determine whether the histone deacetylase inhibitor, depsipeptide FR901228 (DP), could enhance NY-ESO-1 induction mediated by the DNA demethylating agent 5-Aza-2"-deoxycytidine (DAC) in cell lines established primarily from thoracic cancers. Depsipeptides cancer/testis antigen 1A Homo sapiens