Title : Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.

Pub. Date : 2001 Jun 8

PMID : 11262417






2 Functional Relationships(s)
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1 Compounds of the 7,8-benzoflavone class, which are structurally intermediate between flavones and benzo[c]quinoliziniums, were effective CFTR activators with the most potent being 2-(4-pyridinium)benzo[h]4H-chromen-4-one bisulfate (UCcf-029). alpha-naphthoflavone CF transmembrane conductance regulator Homo sapiens
2 These results establish an efficient screening procedure to identify CFTR activators and inhibitors and have identified 7,8-benzoflavones and pyrazolo derivatives as novel classes of CFTR activators. alpha-naphthoflavone CF transmembrane conductance regulator Homo sapiens