Title : Kinetic analysis of the slow ionization of glutathione by microsomal glutathione transferase MGST1.

Pub. Date : 2001 Mar 20

PMID : 11258959






1 Functional Relationships(s)
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1 GSH binding to MGST1 as measured by thiolate anion formation, proton release, and Meisenheimer complex formation is a slow process that can be described by a rapid binding step (K(GSH)d = 47 +/- 7 mM) of the peptide followed by slow deprotonation (k2 = 0.42 +/- 0.03 s(-1). thiolate anion microsomal glutathione S-transferase 1 Homo sapiens