Title : [The mechanism of the anticonvulsive action of diazepam].

Pub. Date : 1975 Mar

PMID : 1125412






1 Functional Relationships(s)
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1 Using this test an antagonistic relationship was observed between diazepam on the one hand, and biculline and thiosemicarbazide--on the other Diazepam was capable of increasing GABA content in the brain by suppressing GABA-transaminase activity in the mitochondrial fraction of the brain tissue. Diazepam 4-aminobutyrate aminotransferase Homo sapiens