Title : Differential regulation of Cl- transport proteins by PKC in Calu-3 cells.

Pub. Date : 2001 Apr

PMID : 11238015






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 mRNA expression of Cl- transporters was semiquantitated by RT-PCR after transfection with a sense or antisense oligonucleotide to the PKC isotypes that modulate the activity of the cystic fibrosis transmembrane conductance regulator [CFTR (PKC-epsilon)] or of the Na/K/2Cl (NKCC1) cotransporter (PKC-delta). Oligonucleotides protein kinase C delta Homo sapiens
2 The antisense oligonucleotide to PKC-delta did not affect CFTR function but did block alpha(1)-adrenergic activation of NKCC1 and reduce PKC-delta mass. Oligonucleotides protein kinase C delta Homo sapiens
3 The antisense oligonucleotide to PKC-delta did not affect CFTR function but did block alpha(1)-adrenergic activation of NKCC1 and reduce PKC-delta mass. Oligonucleotides protein kinase C delta Homo sapiens