Title : Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.

Pub. Date : 2001 Mar 1

PMID : 11230124

1 Functional Relationships(s)
Compound Name
Protein Name
1 We propose a multi-step process, whereby catalytically active processed or unprocessed caspase-9 initially binds the Apaf-1 apoptosome in cytochrome c/dATP-activated lysates and consequently recruits caspase-3 via an interaction between the active site cysteine (C287) in caspase-9 and a critical aspartate (D175) in caspase-3. Cysteine caspase 3 Homo sapiens